How long does it take for poison ivy blisters to go away?

Blisters can form as part of your body's natural reaction to the resin (urushiol) from poison ivy and oak plants. A rash can last anywhere from 1-2 weeks, or up to 30+ days in more severe cases. It is best not to pop the blisters to avoid a potential infection and let them run their course naturally. If you've had an active rash for 2 weeks with little to no success with over-the-counter treatments, we recommend contacting your physician.